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Authors: Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Erik Nimmer, Colin Thomas, Trisha Viswanathan, Alexandra Wolf, Victor Garcia, Petra Rocic, Yongho Bae, Sm Shafiqul Alam, Sachin A Gupte Obesity contributes to liver and cardiovascular diseases, but the underlying multi‑organ mechanisms remain unclear. This study shows that glucose‑6‑phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway, drives obesit

Authors: Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D'Silva, Rajamma Mathew, Francesca Cendali, Angelo D'Alessandro, S M Shafiqul Alam, Victor Garcia, Joseph M Miano, Sachin A Gupte This study examined the role of an X-linked G6PD variant (N126D), prevalent in individuals of African ancestry, in vascular endothelial growth factor receptor blocker–induced pulmonary hypertension. Using CRISPR-engineered rats, we found that the G6PDN126D variant exacerbated pul

Authors: Christina Signoretti, Samuel Fatehi, Rhonda Drewes, Francesca Cendali, Monika Dzieciatkowska, Angelo D'Alessandro, Yongho Bae, Sachin A Gupte Summary: Pulmonary fibrosis is driven in part by oxidative stress and altered metabolism, yet the role of glucose metabolism in extracellular matrix (ECM) synthesis remains unclear. Using a bleomycin-induced rat model, we found that a loss-of-function G6PD variant (G6PDS188F) markedly exacerbates lung fibrosis compared with wil