Research Highlights

Welcome to The Gupte Lab, where our mission is to advance the field of pharmacology through innovative research and collaborative efforts. Dive into our latest studies and explore the remarkable contributions of our dedicated team.

Potential Compensatory Role of Ten-Eleven Translocation (TET)3 in Vascular Smooth Muscle Cell Plasticity

Authors: Melinee D’Silva, Comfort Williams and Sachin A. Gupte This poster presentation, co-authored by Melinee D'Silva and colleagues, explores the role of Ten-Eleven Translocation (TET) enzymes—specifically investigating a potential compensatory role for TET3—in vascular smooth muscle cell (VSMC) plasticity during atherosclerosis. The study examines phenotypic switching, where human coronary artery smooth muscle cells (hCASMCs) shift from a healthy contractile state to a di

G6PD-deficiency Mitigates Gender-dependent Differences in the Aortic Stiffness in Rats

Authors: Samuel Fatehi, Aaditya Gupte, Christina Signoretti, Melinee D’silva, Sachin Gupte This poster presentation, co-authored by Samuel Fatehi and colleagues investigates how glucose-6-phosphate dehydrogenase (G6PD) deficiency impacts gender-dependent differences in large artery stiffness using a rat model. The study highlights that wild-type male rats exhibit significantly higher aortic stiffness—measured via pulse wave velocity (PWV)—compared to wild-type females, which

Metabolic Syndrome–Associated Pulmonary Hypertension: Role ofEndothelin-1 and Inflammatory Signaling in a High-Fat Diet Model

Authors: Adrian Chimbo, Melinee D’Silva , Christina Signoretti1 , Ashley Linton-Edwards , and Sachin A. Gupte This poster presentation, co-authored by Adrian Chimbo and colleagues, investigates the underlying mechanisms linking metabolic syndrome to an increased risk of pulmonary arterial hypertension (PAH) using a high-fat diet (HFD) rat model. The study demonstrates that rats fed an HFD exhibit altered pulmonary function, characterized by a decreased pulmonary artery accel

Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats

Authors: Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Erik Nimmer, Colin Thomas, Trisha Viswanathan, Alexandra Wolf, Victor Garcia, Petra Rocic, Yongho Bae, Sm Shafiqul Alam, Sachin A Gupte Obesity contributes to liver and cardiovascular diseases, but the underlying multi‑organ mechanisms remain unclear. This study shows that glucose‑6‑phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway, drives obesit

G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease

Authors: Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D'Silva, Rajamma Mathew, Francesca Cendali, Angelo D'Alessandro, S M Shafiqul Alam, Victor Garcia, Joseph M Miano, Sachin A Gupte This study examined the role of an X-linked G6PD variant (N126D), prevalent in individuals of African ancestry, in vascular endothelial growth factor receptor blocker–induced pulmonary hypertension. Using CRISPR-engineered rats, we found that the G6PDN126D variant exacerbated pul