News & Updates

Potential Compensatory Role of Ten-Eleven Translocation (TET)3 in Vascular Smooth Muscle Cell Plasticity

Authors: Melinee D’Silva, Comfort Williams and Sachin A. Gupte This poster presentation, co-authored by Melinee D'Silva and colleagues, explores the role of Ten-Eleven Translocation (TET) enzymes—specifically investigating a potential compensatory role for TET3—in vascular smooth muscle cell (VSMC) plasticity during atherosclerosis. The study examines phenotypic switching, where human coronary artery smooth muscle cells (hCASMCs) shift from a healthy contractile state to a di

Jul 7

G6PD-deficiency Mitigates Gender-dependent Differences in the Aortic Stiffness in Rats

Authors: Samuel Fatehi, Aaditya Gupte, Christina Signoretti, Melinee D’silva, Sachin Gupte This poster presentation, co-authored by Samuel Fatehi and colleagues investigates how glucose-6-phosphate dehydrogenase (G6PD) deficiency impacts gender-dependent differences in large artery stiffness using a rat model. The study highlights that wild-type male rats exhibit significantly higher aortic stiffness—measured via pulse wave velocity (PWV)—compared to wild-type females, which

Jul 7

Metabolic Syndrome–Associated Pulmonary Hypertension: Role ofEndothelin-1 and Inflammatory Signaling in a High-Fat Diet Model

Authors: Adrian Chimbo, Melinee D’Silva , Christina Signoretti1 , Ashley Linton-Edwards , and Sachin A. Gupte This poster presentation, co-authored by Adrian Chimbo and colleagues, investigates the underlying mechanisms linking metabolic syndrome to an increased risk of pulmonary arterial hypertension (PAH) using a high-fat diet (HFD) rat model. The study demonstrates that rats fed an HFD exhibit altered pulmonary function, characterized by a decreased pulmonary artery accel

Jul 7

Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats

Authors: Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Erik Nimmer, Colin Thomas, Trisha Viswanathan, Alexandra Wolf, Victor Garcia, Petra Rocic, Yongho Bae, Sm Shafiqul Alam, Sachin A Gupte Obesity contributes to liver and cardiovascular diseases, but the underlying multi‑organ mechanisms remain unclear. This study shows that glucose‑6‑phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway, drives obesit

Apr 24

G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease

Authors: Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D'Silva, Rajamma Mathew, Francesca Cendali, Angelo D'Alessandro, S M Shafiqul Alam, Victor Garcia, Joseph M Miano, Sachin A Gupte This study examined the role of an X-linked G6PD variant (N126D), prevalent in individuals of African ancestry, in vascular endothelial growth factor receptor blocker–induced pulmonary hypertension. Using CRISPR-engineered rats, we found that the G6PDN126D variant exacerbated pul

Apr 23

Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency

Authors: Christina Signoretti, Samuel Fatehi, Rhonda Drewes, Francesca Cendali, Monika Dzieciatkowska, Angelo D'Alessandro, Yongho Bae, Sachin A Gupte Summary: Pulmonary fibrosis is driven in part by oxidative stress and altered metabolism, yet the role of glucose metabolism in extracellular matrix (ECM) synthesis remains unclear. Using a bleomycin-induced rat model, we found that a loss-of-function G6PD variant (G6PDS188F) markedly exacerbates lung fibrosis compared with wil

Apr 23