<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0"><channel><title><![CDATA[The Gupte Lab]]></title><description><![CDATA[The Gupte Lab]]></description><link>https://www.guptelab.com/news</link><generator>RSS for Node</generator><lastBuildDate>Fri, 05 Jun 2026 08:48:26 GMT</lastBuildDate><atom:link href="https://www.guptelab.com/blog-feed.xml" rel="self" type="application/rss+xml"/><item><title><![CDATA[Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats]]></title><description><![CDATA[Authors: Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Erik Nimmer, Colin Thomas, Trisha Viswanathan, Alexandra Wolf, Victor Garcia, Petra Rocic, Yongho Bae, Sm Shafiqul Alam, Sachin A Gupte Obesity contributes to liver and cardiovascular diseases, but the underlying multi‑organ mechanisms remain unclear. This study shows that glucose‑6‑phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway, drives obesity‑related...]]></description><link>https://www.guptelab.com/post/loss-of-function-g6pd-variant-moderated-high-fat-diet-induced-obesity-adipocyte-hypertrophy-and-fa</link><guid isPermaLink="false">69eb83ff81e17196bd24af4e</guid><category><![CDATA[Publications]]></category><pubDate>Fri, 24 Apr 2026 14:58:32 GMT</pubDate><dc:creator>Darren Lobo</dc:creator></item><item><title><![CDATA[G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease]]></title><description><![CDATA[Authors: Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D'Silva, Rajamma Mathew, Francesca Cendali, Angelo D'Alessandro, S M Shafiqul Alam, Victor Garcia, Joseph M Miano, Sachin A Gupte This study examined the role of an X-linked G6PD variant (N126D), prevalent in individuals of African ancestry, in vascular endothelial growth factor receptor blocker–induced pulmonary hypertension. Using CRISPR-engineered rats, we found that the G6PDN126D variant exacerbated pulmonary...]]></description><link>https://www.guptelab.com/post/g6pdn126d-variant-increases-the-risk-of-developing-vegfr-vascular-endothelial-growth-factor-recepto</link><guid isPermaLink="false">69eaa06db17cf497ceb4defd</guid><category><![CDATA[Publications]]></category><pubDate>Thu, 23 Apr 2026 22:45:32 GMT</pubDate><dc:creator>Darren Lobo</dc:creator></item><item><title><![CDATA[Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency]]></title><description><![CDATA[Authors: Christina Signoretti, Samuel Fatehi, Rhonda Drewes, Francesca Cendali, Monika Dzieciatkowska, Angelo D'Alessandro, Yongho Bae, Sachin A Gupte Summary: Pulmonary fibrosis is driven in part by oxidative stress and altered metabolism, yet the role of glucose metabolism in extracellular matrix (ECM) synthesis remains unclear. Using a bleomycin-induced rat model, we found that a loss-of-function G6PD variant (G6PDS188F) markedly exacerbates lung fibrosis compared with wild-type controls,...]]></description><link>https://www.guptelab.com/post/bleomycin-induced-lung-fibrosis-and-dysfunction-is-exacerbated-by-g6pd-deficiency</link><guid isPermaLink="false">69ea9eb2b17cf497ceb4db9c</guid><category><![CDATA[Publications]]></category><pubDate>Thu, 23 Apr 2026 22:40:31 GMT</pubDate><dc:creator>Darren Lobo</dc:creator></item><item><title><![CDATA[Meet Our Team: Experts Behind Gupte Lab Research]]></title><description><![CDATA[At Gupte Lab, we pride ourselves on having a diverse and talented team dedicated to advancing research in various fields. Our experts bring unique skills and perspectives that drive innovation and discovery. In this blog post, we will introduce you to some of the key members of our team, highlighting their backgrounds, expertise, and contributions to our ongoing projects. Meet Our Team Members Dr. Sachin Gupte - Principal Investigator Dr. Melinee D' Silva - Senior Research Scientist Comfort...]]></description><link>https://www.guptelab.com/post/meet-our-team-experts-behind-gupte-lab-research</link><guid isPermaLink="false">69ea5a0cab5395dde6092572</guid><category><![CDATA[News]]></category><pubDate>Thu, 23 Apr 2026 17:42:36 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/e3f8d1_53b5cc2f68c74ad9bd7d85e9037b2f8b~mv2.jpeg/v1/fit/w_450,h_600,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>Darren Lobo</dc:creator></item><item><title><![CDATA[We are attending the American Physiology Summit 2026]]></title><description><![CDATA[The American Physiology Summit 2026 is a major international scientific meeting organized by the American Physiological Society (APS) that brings together researchers, clinicians, educators, and trainees across all areas of physiology. The summit serves as a collaborative forum to share cutting‑edge discoveries, explore how physiological systems interact in health and disease, and highlight emerging technologies and translational research. Through plenary lectures, symposia, poster sessions,...]]></description><link>https://www.guptelab.com/post/innovative-pharmacology-research-at-the-gupte-lab</link><guid isPermaLink="false">69ea5a00bbc0f3ff744937c7</guid><category><![CDATA[News]]></category><pubDate>Thu, 23 Apr 2026 17:42:24 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/e3f8d1_64abb19df4d5473cbe91ea37078f8201~mv2.jpeg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>Darren Lobo</dc:creator></item></channel></rss>